Granulomatous slack skin: a rare subtype of mycosis fungoides.

We report a case of granulomatous slack skin, a rare and indolent subtype of mycosis fungoides. It affects mainly men between the third and fourth decades. It is characterized by hardened and erithematous plaques that mainly affect flexural areas and become pedunculated after some years. Histological examination shows a dense infiltrate of small atypical lymphocytes involving the dermis (and sometimes the subcutaneous tissue) associated with histiocytic and multinucleated giant cells containing lymphocytes and elastic fibers (lymphophagocytosis and elastophagocytosis, respectively). Patients affected by this entity can develop secondary lymphomas. There are several but little effective therapeutic modalities described. Despite the indolent behavior of granulomatous slack skin, its early recognition and continuous monitoring by a dermatologist becomes essential for its management and prevention of an unfavorable outcome.

Granulomatous slack skin: a rare subtype of mycosis fungoides

Abstract: We report a case of granulomatous slack skin, a rare and indolent subtype of mycosis fungoides. It affects mainly men between the third and fourth decades. It is characterized by hardened and erithematous plaques that mainly affect flexural areas and become pedunculated after some years. Histological examination shows a dense infiltrate of small atypical lymphocytes involving the dermis (and sometimes the subcutaneous tissue) associated with histiocytic and multinucleated giant cells containing lymphocytes and elastic fibers (lymphophagocytosis and elastophagocytosis, respectively). Patients affected by this entity can develop secondary lymphomas. There are several but little effective therapeutic modalities described. Despite the indolent behavior of granulomatous slack skin, its early recognition and continuous monitoring by a dermatologist becomes essential for its management and prevention of an unfavorable outcome.

Carcinoma de células de Merkel: apresentação clínica, dermatoscópica e imuno-histoquímica de um tumor raro / Merkel cell carcinoma: clinical, dermoscopic and immunohistochemicalaspects of a rare tumor

Carcinoma de células de Merkel é tumor cutâneo neuroendócrino raro e altamente agressivo. Objetiva-se neste artigo alertar para a possibilidade desse diagnóstico, geralmente não considerado hipótese inicial em neoplasias cutâneas. Relatamos dois casos de pacientes do sexo feminino, idosas com queixa de nódulo único eritematoso na face. Aventaram-se hipóteses diagnósticas de carcinoma basocelular e melanoma amelanótico. À dermatoscopia foi evidente a presença de telangiectasias O exame histopatológico da biópsia incisional diagnosticou carcinoma de células de Merkel. Essa neoplasia ocorre tipicamente em pacientes brancos, acima de 65 anos, manifestando-se como nódulo eritêmato-violáceo, de crescimento rápido, sendo a imuno-histoquímica essencial para o diagnóstico.

The Merkel cell carcinoma is a rare and highly aggressive neuroendocrine skin tumor. The purpose of this paper is to warn of the possibility of this diagnosis, usually not considered as an initial hypothesis in cutaneous neoplasias. The authors describe two cases of elderly female patients with complaints of a single erythematous nodule on the face. The diagnoses of basal cell carcinoma and amelanotic melanoma were considered. The presence of telangiectasias was evident at dermoscopy. The incisional biopsy's histology evidenced Merkel cell carcinomas. This neoplasia typically occurs in Caucasian patients with over 65 years of age, emerging as an erythematous-purplish nodule of rapid growth, with immunohistochemistry being essential for the diagnosis.